Patrick H van Berkel Selected Research

pyrrolo(2,1-c)(1,4)benzodiazepine

1/2022	Preclinical Development of ADCT-601, a Novel Pyrrolobenzodiazepine Dimer-based Antibody-drug Conjugate Targeting AXL-expressing Cancers.
1/2020	The Role of Specific ATP-Binding Cassette Transporters in the Acquired Resistance to Pyrrolobenzodiazepine Dimer-Containing Antibody-Drug Conjugates.
10/2018	Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody-Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer.
11/2016	ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer-Containing Antibody-Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies.

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Patrick H van Berkel Research Topics

Disease

8	Neoplasms (Cancer) 01/2022 - 11/2016
2	Hematologic Neoplasms (Hematological Malignancy) 01/2022 - 11/2016
2	Lung Neoplasms (Lung Cancer) 01/2022 - 01/2019
2	Lymphoma (Lymphomas) 01/2018 - 11/2016
1	Ovarian Neoplasms (Ovarian Cancer) 01/2022
1	Adenocarcinoma 01/2020
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2020
1	Prostatic Neoplasms (Prostate Cancer) 10/2018
1	Leukemia 01/2018

Drug/Important Bio-Agent (IBA)

7	Immunoconjugates (Immunoconjugate)IBA 01/2022 - 11/2016
4	pyrrolo(2,1-c)(1,4)benzodiazepineIBA 01/2022 - 11/2016
4	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 11/2016
2	Pharmaceutical PreparationsIBA 01/2020 - 01/2019
2	AntigensIBA 01/2019 - 10/2018
1	monomethyl auristatin EIBA 01/2022
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2022
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2022
1	auristatinIBA 01/2022
1	olaparibIBA 01/2022
1	IntegrinsIBA 01/2020
1	Programmed Cell Death 1 ReceptorIBA 01/2020
1	Peptides (Polypeptides)IBA 01/2020
1	apomabIBA 01/2019
1	Proteins (Proteins, Gene)FDA Link 01/2019
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2019
1	Monoclonal AntibodiesIBA 01/2019
1	MEDI3726IBA 10/2018
1	glutamate carboxypeptidaseIBA 10/2018
1	Histones (Histone)IBA 10/2018
1	Immunoglobulins (Immunoglobulin)IBA 01/2018
1	loncastuximab tesirineIBA 01/2018
1	Membrane Glycoproteins (Membrane Glycoprotein)IBA 01/2018
1	CD19 AntigensIBA 01/2018
1	Tubulin ModulatorsIBA 01/2018

Therapy/Procedure

2	Therapeutics 01/2020 - 01/2019
1	Immunotherapy 01/2020
1	Drug Therapy (Chemotherapy) 01/2019
1	Castration 10/2018